The Common Mechanism is designed to screen DNA and RNA sequences. While it can handle standard sequences, there are some limitations:

• It cannot currently screen protein sequences directly, though translations of the input DNA sequences are screened as part of the process.

• The system does not have specialized functionality for screening oligo orders.

• Each input sequence in the FASTA file is screened individually.

• The pipeline cannot currently process sequences containing ambiguity codons.

• It cannot screen sequences shorter than 50 nucleotides

IBBIS is constantly working on reducing these restrictions, which should gradually disappear as new updates are released.