The Common Mechanism sequence screening was developed with a dual emphasis on reducing ambiguities and flagging a baseline level of sequences of concern, making it a useful tool for benchtop synthesis devices. The decision support tool is able to provide a fully automated “flag” or “pass” decision for each order; benchtop devices could then be configured to refuse to synthesize sequences that are flagged during screening. Legitimate users of those sequences would need to order them from another commercial provider or provide an authentication key that allows them to synthesize specific sequences of concern.