The Common Mechanism is designed to screen DNA and RNA sequences. There are some limitations:

• Sequences below 50bp cannot be screened, and screening performance is best with sequences over 150bp.
• Protein sequences cannot be screened directly, though translations of the input DNA sequences are screened as part of the process.
• The system does not have any specialized functionality for screening oligo orders.
• Sequences containing ambiguity codons may not be scored correctly by every step in the pipeline.

IBBIS is working on reducing these limitations.