The global landscape of DNA synthesis remains unclear, with limited visibility into where synthetic DNA is produced, how providers screen their orders, and what regulations apply. IBBIS is creating a comprehensive picture of the DNA synthesis market through surveys, open-source research and stakeholder interviews. Our Global DNA Synthesis Map will fill information gaps about current screening practices, potential vulnerabilities, and where advocacy is needed to close biosecurity gaps.
As DNA synthesis becomes more affordable, accessible, and globally distributed, there is an increased risk that synthetic DNA could be misused to create an modify potentially dangerous biological agents. As IBBIS works to increase the share of synthesis orders that are screened by developing tools for sequence and customer screening, we faced important uncertainties: which companies are currently selling synthetic DNA or benchtop DNA printers? Are these companies employing robust screening measures? How is potentially dangerous DNA currently accessed around the world? What policies already govern the production and transfer of synthetic DNA? Where would advocacy for new standards or regulations have the greatest impact?
IBBIS is tackling these uncertainties head-on. We began by gathering insights from associations like the Global Biofoundries Alliance and International Gene Synthesis Consortium, market research reports, and direct communications with industry experts and pathogen scientists. However, many existing information sources were incomplete or outdated, obscuring the current state of synthetic DNA production and transfer. Given its potential to create new pathogens and other biosecurity risks, mapping the production, screening practices, distribution networks, and regulatory oversight of synthetic DNA is essential for safeguarding public health and security.
Our goal is to build a comprehensive, global map of the synthetic DNA landscape that will both highlight current gaps and provide foundation for implementing standardized screening practices worldwide.
Our Global Synthesis Map will be publicly accessible, and we will produce additional tailored resources for policymakers, industry, and biosecurit professionals. By illuminating DNA synthesis practices worldwide, we aim to promote responsible oversight, minimize misuse risks, and safeguard scientifi advancement. To build the map, our work includes:
This structured, collaborative approach will create an actionable resource that strengthens biosecurity while supporting scientific progress.
Mayra Ameneiros